In 2006, Arup received his M.Sc. in Biochemistry from Calcutta University, and subsequently, in 2012, he completed his Ph.D. in Cell Biology at the Stowers Institute in Kansas City (KC), where he was under the mentorship of Rong Li. Following the successful completion of his Ph.D., Arup embarked on postdoctoral research, first with Clare Waterman at the National Institutes of Health (NIH), and later with Donald Zack at Johns Hopkins University.

In November 2019, he established his own independent laboratory at the Indiana University School of Medicine (IUSM). In his research, Arup employs a multidisciplinary approach, utilizing stem cells, neurobiology, drug screening, and animal models. His primary objective is to uncover the mechanisms of neurodegeneration at the single-cell level, with the ultimate goal of developing neuroprotection therapies for conditions such as glaucoma and amyotrophic lateral sclerosis (ALS). Arup’s lab has discovered several small molecules  using human stem cell differentiated RGCs and drug screening that shows restoration of mitochondrial homeostasis with glaucoma neuroprotection effect. Ongoing research in Arup’s lab is elucidating the mechanism of action for above compound.   

Beyond his professional endeavors, Arup finds great fulfillment in various outdoor activities, including soccer, hiking, and swimming.